Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing.

Nucleic acids research - 1 Apr 2010

Goers Emily S, Purcell Jamie, Voelker Rodger B, Gates Devika P, Berglund J Andrew

Abstract excerpt

Muscleblind-like 1 (MBNL1) regulates alternative splicing and is a key player in the disease mechanism of myotonic dystrophy (DM). In DM, MBNL1 becomes sequestered to expanded CUG/CCUG repeat RNAs resulting in splicing defects, which lead to disease symptoms. In order to understand MBNL1's role in both the disease mechanism of DM and alternative splicing regulation, we sought to identify its RNA-binding motif. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GC Rich Sequence
Share to Alternative Splicing
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Muscular Dystrophies

Share to Pyrimidines

Share to RNA Precursors

Share to Sarcoplasmic Reticulum Calcium-Transporting ATPases

Share to Sequence Analysis, RNA

Source

Open in PubMed Open full text

Identifiers

PMID: 20071745
DOI: 10.1093/nar/gkp1209
PMCID: PMC2853123

Genes

MBNL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing.PMID 20071745Read ↗

MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin TSemantic proximity Read ↗

Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 1.Semantic proximity Read ↗

Pathogenic mechanisms of myotonic dystrophy.Semantic proximity Read ↗

MBNL1–RNA Recognition: Contributions of MBNL1 Sequence and RNA ConformationSemantic proximity Read ↗

The four Zn fingers of MBNL1 provide a flexible platform for recognition of its RNA binding elementsSemantic proximity Read ↗

The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicingSemantic proximity Read ↗

MicroRNA-Based Therapeutic Perspectives in Myotonic DystrophySemantic proximity Read ↗

Co-opting MBNL-dependent alternative splicing cassette exons to control gene therapy in myotonic dystrophySemantic proximity Read ↗

Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAsSemantic proximity Read ↗

Autoregulated Splicing of muscleblind-like 1 (MBNL1) Pre-mRNASemantic proximity Read ↗

An Overview of Alternative Splicing Defects Implicated in Myotonic Dystrophy Type ISemantic proximity Read ↗

RNA binding specificity of Drosophila muscleblind.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.