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Article

MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing.

Nucleic acids research - 1 Apr 2010

Goers Emily S, Purcell Jamie, Voelker Rodger B, Gates Devika P, Berglund J Andrew

Abstract excerpt

Muscleblind-like 1 (MBNL1) regulates alternative splicing and is a key player in the disease mechanism of myotonic dystrophy (DM). In DM, MBNL1 becomes sequestered to expanded CUG/CCUG repeat RNAs resulting in splicing defects, which lead to disease symptoms. In order to understand MBNL1's role i...

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Source

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Identifiers

PMID: 20071745
DOI: 10.1093/nar/gkp1209
PMCID: PMC2853123

Genes

MBNL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20071745-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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