Article

Splice-switching of the insulin receptor in rhabdomyosarcoma: Rescuing the <i>IR-B</i> isoform for better treatment options

2020-10-02

Abstract excerpt

<h4>ABSTRACT</h4> Rhabdomyosarcoma (RMS) is an aggressive pediatric tumor with poor prognosis for metastasis and recurrent disease. Large scale sequencing endeavors demonstrate that RMS tumors have limited mutations and a dearth of driver mutations that are precisely targetable. However, IGF2 signaling is known to be grossly altered in RMS. The IGF2 signalling molecule binds both its innate IGF1 receptor as well...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a34d3224-e66a-55ac-bfc0-7520a2e18bf9
DOI: 10.1101/2020.10.02.324053

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Splice-switching of the insulin receptor in rhabdomyosarcoma: Rescuing the <i>IR-B</i> isoform for better treatment optionsDOI 10.1101/2020.10.02.324053Read

Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcomaSemantic proximity Read

Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and ChemoresistanceSemantic proximity Read

Role of Alternatively Spliced Messenger RNA (mRNA) Isoforms of the Insulin-Like Growth Factor 1 (IGF1) in Selected Human TumorsSemantic proximity Read

Transcriptomic profiling of recurrent Rhabdomyosarcoma: Pre- and post-treatment tissue analysis reveals molecular characteristics of acquired resistance.Semantic proximity Read

Altered Expression of Insulin Receptor Isoforms in Breast CancerSemantic proximity Read

The IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer: Actionable PerspectivesSemantic proximity Read

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and DiseaseSemantic proximity Read

Subventricular zone adult mouse neural stem cells and human glioblastoma stem cells require insulin receptor for self-renewalSemantic proximity Read

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.Semantic proximity Read

Deep Sequencing the microRNA profile in rhabdomyosarcoma reveals down-regulation of miR-378 family membersSemantic proximity Read

CRISPR‐Cas9–induced IGF1 gene activation as a tool for enhancing muscle differentiation via multiple isoform expressionSemantic proximity Read

SNAI2-mediated direct repression of <i>BIM</i> protects rhabdomyosarcoma from ionizing radiationSemantic proximity Read