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Article

Mutational analysis of the U12-dependent branch site consensus sequence.

RNA (New York, N.Y.) - 1 Nov 2008

Brock Jay E, Dietrich Rosemary C, Padgett Richard A

Abstract excerpt

Highly conserved sequences at the 5' splice site and branch site of U12-dependent introns are important determinants for splicing by U12-dependent spliceosomes. This study investigates the in vivo splicing phenotypes of mutations in the branch site consensus sequence of the U12-dependent intron F from a human NOL1 (P120) minigene. Intron F contains a fully consensus branch site sequence (UUCCUUAAC). Mutations at...

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Identifiers

PMID: 18824513
DOI: 10.1261/rna.1189008
PMCID: PMC2578861

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Source receipt: pubmed, retrieved 7 Sept 2026.

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