Article

Evaluating cancer cell line and patient-derived xenograft recapitulation of tumor and non-diseased tissue gene expression profiles <i>in silico</i>

2023-04-13

Abstract excerpt

Preclinical models like cancer cell lines and patient-derived xenografts (PDXs) are vital for studying disease mechanisms and evaluating treatment options. It is essential that they accurately recapitulate the disease state of interest to generate results that will translate in the clinic. Prior studies have demonstrated that preclinical models do not recapitulate all biological aspects of human tissues, particula...

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Literature Corpus work: 69544618-6dfd-55fe-b929-1c9222f26cac
DOI: 10.1101/2023.04.11.536431

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