Finding the best cell lines across pan-cancer to use in pre-clinical research as a proxy for patient tumor samples considering immune cells, multi-omics, and cancer pathways

Abstract excerpt

In pre-clinical trials of anti-cancer drugs, cell lines are utilized as a model for patient tumor samples to understand the response of drugs. However, in vitro culture of cell lines, in general, alters the biology of the cell lines and likely gives rise to systematic differences from the tumor samples’ genomic profiles; hence the drug response of cell lines may deviate from actual patients’ drug response. In thi...

Topics

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• Cancer Genomics and Diagnostics
• Cell Line, Tumor
• Gene Expression
• Gene expression and cancer classification
• Gene Expression Profiling
• Genomics
• Mutation
• Pancreatic and Hepatic Oncology Research

Identifiers and source

Literature Corpus work

14dda5db-4a45-590f-816f-54666e1126ac

DOI

10.1101/2022.12.18.520831