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Longitudinal whole-exome sequencing of cell-free DNA unravels the metastatic evolutionary dynamics of <i>BRCA2</i> -mutated breast cancer

2020-01-10

Abstract excerpt

Little is known about the metastatic evolutionary dynamics of BRCA2 -mutated cancers. Here, we applied whole-exome sequencing (WES) of primary tumor (PT), local relapse (LR) and eight serial plasma cfDNA samples collected from disease progression to depict the 12 years evolutionary trajectory of a metastatic BRCA2 -mutated breast cancer. While longitudinal WES-cfDNA recapitulated clonal and subclonal mutations a...

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Literature Corpus work
69449a4f-b811-58ed-b3aa-45eb22205f30
DOI
10.1101/2020.01.10.901330
Open publication

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Longitudinal whole-exome sequencing of cell-free DNA unravels the metastatic evolutionary dynamics of <i>BRCA2</i> -mutated breast cancerDOI 10.1101/2020.01.10.901330
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