Article

Unraveling the underlying mechanisms of cancer stem cells in therapeutic resistance for optimizing treatment strategies

2025-01-10

Abstract excerpt

Abstract The success of cancer therapy has been significantly hampered by various mechanisms of therapeutic resistance. Chief among these mechanisms is the presence of clonal heterogeneity within an individual tumor mass. The introduction of the concept of cancer stem cells (CSCs)—a rare and immature subpopulation with tumorigenic potential that contributes to intratumoral heterogeneity—has deepened our understand...

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Literature Corpus work: 68fd4ecf-ef26-510c-b03c-1f8026696431
DOI: 10.1002/mog2.70009

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