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Cancer Stem Cells: A New Paradigm for Understanding Tumor Growth and Progression and Drug Resistance

1 May 2009

Abstract excerpt

Normal somatic stem cells (SC) are naturally resistant to chemotherapeutic agents due to their expression of various membrane transporter molecules (such as MDR-1), detoxifying enzymes and DNA repair proteins. In addition, they also have a slow rate of cell turnover and therefore escape from chemotherapeutic agents that target rapidly replicating cells. Cancer stem cells (CSC), being the mutated counterparts of...

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PMID: 19442140
DOI: 10.2174/092986709788186147

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