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Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents

15 Feb 2021

Abstract excerpt

Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that contribute to tumor progression and therapy resistance. However, the underlying processes are still unclear. Elucidation of the key hallmarks and resistance mechanisms of CSCs may help improve patient outcomes and reduce relapse by altering therapeutic regimens. Here, we reviewed the identification of CSCs, the intrinsic and...

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PMID: 33589595
DOI: 10.1038/s41392-020-00430-1

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