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Stem cell programs in cancer initiation, progression, and therapy resistance

1 Jan 2020

Abstract excerpt

Over the past few decades, substantial evidence has convincingly revealed the existence of cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly high degree of cellular heterogeneity within the tumor. CSCs are functionally defined by their abilities of self-renewal and differentiation, often in response to cues from their microenvironment. Biological phenotypes of CSCs are...

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PMID: 32754274
DOI: 10.7150/thno.41648

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