Multi-modal refinement of the human heart atlas during the first gestational trimester

Abstract excerpt

1. Forty first-trimester human hearts were studied to lay groundwork for further studies of principles underlying congenital heart defects. We first sampled 49,227 cardiac nuclei from three fetuses at 8.6, 9.0, and 10.7 post-conceptional weeks (pcw) for single-nucleus RNA sequencing, enabling distinction of six classes comprising 21 cell types. Improved resolution led to identification of novel cardiomyocytes and...

Topics

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• Cardiac Fibrosis and Remodeling
• Cardiomyopathy and Myosin Studies
• Congenital heart defects research
• Congenital Heart Disease Studies

Identifiers and source

Literature Corpus work

9c3a5ab9-85f2-539a-8a8d-7b905fb78c34

DOI

10.1101/2024.11.21.624698