Article

Tmem178 negatively regulates IL-1β production through inhibition of the NLRP3 inflammasome

2023-03-07

Abstract excerpt

<h4>Objective</h4> Inflammasomes modulate the release of bioactive IL-1β. Excessive IL-1β levels are detected in patients with systemic juvenile idiopathic arthritis (sJIA) and cytokine storm syndrome (CSS) with mutated and unmutated inflammasome components, raising questions on the mechanisms of IL-1β regulation in these disorders. <h4>Methods</h4> To investigate how the NLRP3 inflammasome is modulated in sJIA,...

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Literature Corpus work: 68f0790a-f384-510f-871c-24f98489db5f
DOI: 10.1101/2023.03.07.531385

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