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Article

Physiological and pathophysiological functions of SOCE in the immune system.

Frontiers in bioscience (Elite edition) - 1 Jan 2012

Shaw Patrick J, Feske Stefan

Abstract excerpt

Calcium signals play a critical role in many cell-type specific effector functions during innate and adaptive immune responses. The predominant mechanism to raise intracellular (Ca²⁺) used by most immune cells is store-operated Ca²⁺ entry (SOCE), whereby the depletion of endoplasmic reticulum (ER) Ca²⁺ stores triggers the influx of extracellular Ca²⁺. SOCE in immune cells is mediated by the highly Ca²⁺ selective...

Topics

Animals
Calcium
Calcium Channels
Humans
Immune System
Ion Transport
Membrane Proteins
Mutation
Neoplasm Proteins
ORAI1 Protein
Stromal Interaction Molecule 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 22202035
DOI: 10.2741/e540
PMCID: PMC3774593

Genes

ORAI1
ORAI2
ORAI3
STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Physiological and pathophysiological functions of SOCE in the immune system.PMID 22202035Read ↗

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