Article

Vacuole Membrane Protein 1 (VMP1) Restricts NLRP3 Inflammasome Activation by Modulating SERCA Activity and Autophagy

2023-01-27

Abstract excerpt

<title>Abstract</title> <p>Altered expression of vacuole membrane protein 1 (VMP1) has recently been observed in the context of multiple sclerosis and Parkinson’s disease (PD). However, how changes in VMP1 expression may impact pathogenesis has not been explored. Here, we report that genetic deletion of VMP1 from a monocytic cell line resulted in increased NLRP3 inflammasome activation and release of proinflammat...

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Literature Corpus work: 3d7099f4-cc6a-5f39-af6a-5eb504fa846f
DOI: 10.21203/rs.3.rs-2508369/v1

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