Article

Human hepatocyte systems for in vitro toxicology analysis

2018-09-21

Abstract excerpt

Drug induced liver injury (DILI) is still the leading single cause of drug failure during clinical phases and after market approval. Currently, many laboratories aim to develop appropriate in vitro systems to predict drug hepatotoxicity. Primary human hepatocytes are still the gold standard, but they have substantial disadvantages such as rapid dedifferentiation in vitro and lack of cell proliferation. In addition...

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Literature Corpus work: d08fea8a-c188-5850-8c10-87aeb1ef9390
DOI: 10.3233/jcb-179012

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