Article

Drug metabolic activity is a critical cell-intrinsic determinant for selection of hepatocytes during long-term culture

2021-04-19

Abstract excerpt

<h4>SUMMARY</h4> Hepatocytes can be used to study the pathogenesis of liver diseases and drug discovery research. Human hepatocytes are, however, hardly expandable in vitro making it difficult to secure large numbers of cells from one donor. In this study, we aimed to establish an in vitro long-term culture system that enables stable proliferation and maintenance of human hepatocytes to ensure a constant supply....

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Literature Corpus work: 2048970b-535c-5b8a-a73b-cc57aad0e95b
DOI: 10.1101/2021.04.18.440311

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