Article

ApoE4 causes severe COVID-19 outcomes via downregulation of ACE2

2022-12-09

Abstract excerpt

<h4>Background: </h4> Recent numerous epidemiology and clinical association studies reported that ApoE polymorphism may associate with the risk and severity of coronavirus disease 2019 (COVID-19), and yielded inconsistent results. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection relies on its spike protein binding to angiotensin-converting enzyme 2 (ACE2) receptor expressed on host cell membr...

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Literature Corpus work: 68e58de3-38c0-5ef4-89d5-951c48df625a
DOI: 10.21203/rs.3.rs-2303904/v1

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