Article

ApoE4 causes severe COVID-19 outcomes via downregulation of ACE2

2022-09-05

Abstract excerpt

The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); host cell entry by this virus relies on the interaction between the receptor-binding domain (RBD) of its spike glycoprotein and the angiotensin-converting enzyme 2 (ACE2) receptor on cell membranes. In addition to serving as a receptor for SARS-CoV-2, ACE2 was originally discovered as a prote...

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Literature Corpus work: e39d80fa-367c-5409-8c23-783bdbffe981
DOI: 10.1101/2022.09.04.506474

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