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Article

Mutations in the TERC template sequence can be incorporated into the telomeres of human tumors.

PloS one - 1 Jan 2022

Sharaf Radwa, Frampton Garrett M, Albacker Lee A

Abstract excerpt

Telomerase-mediated lengthening is a mechanism by which some cancer cells avoid senescence-mediated cell cycle arrest due to shortened telomeres. By reverse transcribing an RNA template, encoded by TERC, the enzyme telomerase synthesizes the elongation of telomeric DNA using the 3' end of the chromosome as a primer. TERC harbors a highly conserved template region consisting of 11 nucleotides spanning hg19...

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Identifiers

PMID: 36006930
DOI: 10.1371/journal.pone.0272707
PMCID: PMC9409504

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