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Improvement of affinity and potency of a monoclonal antibody against <i>Shigella flexneri</i> 3a O-antigen via phage display and whole-cell in-solution panning

2025-09-16

Abstract excerpt

As rates of antimicrobial resistance (AMR) among bacterial pathogens continue to rise, the discovery and development of novel classes of therapeutics that can serve as alternatives or adjuncts to traditional small-molecule antibiotics, such as monoclonal antibodies (mAbs), is a public health priority. Some of the most promising antigen targets for antibacterial mAbs are surface polysaccharides such as O-antigen (O...

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Literature Corpus work
eea81b00-f471-5dff-ac9c-ca51e4e96ef0
DOI
10.1101/2025.09.11.675504
Open publication

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Improvement of affinity and potency of a monoclonal antibody against <i>Shigella flexneri</i> 3a O-antigen via phage display and whole-cell in-solution panningDOI 10.1101/2025.09.11.675504
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