Back to search

Article

Rational selection of TbpB variants elucidates a bivalent vaccine formulation with broad spectrum coverage against <i>Neisseria gonorrhoeae</i>

2024-09-07

Abstract excerpt

Neisseria gonorrhoeae is the causative agent of gonorrhea, an on-going public health problem due in part to the lack of success with efforts to develop an efficacious vaccine to prevent this sexually transmitted infection. An attractive candidate vaccine antigen because of its essential function and surface exposure, the gonococcal transferrin binding protein B (TbpB) exhibits high levels of antigenic variability...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0eef114a-8786-5c99-a4d5-da0d0ad85f4c
DOI
10.1101/2024.09.07.611798
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Rational selection of TbpB variants elucidates a bivalent vaccine formulation with broad spectrum coverage against <i>Neisseria gonorrhoeae</i>DOI 10.1101/2024.09.07.611798
Structure-based engineering of a nutrient acquisition protein enhances neutralizing antibodies and protection for the development of a gonococcal vaccineSemantic proximity
Rationally designed minimized TbpB confers broad protection against meningococcal infectionSemantic proximity
Preclinical Evaluation of Novel Conserved <em>Neisseria gonorrhoeae</em> Vaccine Candidates Identified Through Infection-Informed Antigen DiscoverySemantic proximity
An mRNA–Lipid Nanoparticle Platform Encoding the Conserved Outer Membrane Protein BamA Elicits Broadly Cross-Reactive Systemic and Mucosal Antibodies Against Antimicrobial-Resistant <i>Neisseria gonorrhoeae</i>Semantic proximity
Investigating genetic, antigenic, and structural diversity in the Neisseria gonorrhoeae outer membrane protein, PorB: implications for vaccine design.Semantic proximity
Looking beyond meningococcal B with the 4CMenB vaccine: the Neisseria effectSemantic proximity
The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeaeSemantic proximity
Quantitative proteomics of the 2016 WHO <i>Neisseria gonorrhoeae</i> reference strains surveys vaccine candidates and antimicrobial resistance determinantsSemantic proximity
<i>Neisseria meningitidis</i>serogroup B bivalent factor H binding protein vaccineSemantic proximity
Proteomics-driven Antigen Discovery for Development of Vaccines Against GonorrheaSemantic proximity
Genetic Similarity of Gonococcal Homologs to Meningococcal Outer Membrane Proteins of Serogroup B VaccineSemantic proximity
Meningococcal vaccine Bexsero elicits a robust cellular immune response that targets but is not consistently protective against <i>Neisseria gonorrhoeae</i> during murine vaginal infectionSemantic proximity
Select a neighboring publication to make it the new centre.