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A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of <i>Escherichia coli</i> ST131

2020-05-22

Abstract excerpt

The increase of antimicrobial resistance (AMR), and lack of new classes of licensed antimicrobials, have made alternative treatment options for AMR pathogens increasingly attractive. Recent studies have demonstrated anti-bacterial efficacy of a humanised monoclonal antibody (mAb) targeting the O25b O-antigen of Escherichia coli ST131. To evaluate the phenotypic effects of antibody binding to diverse clinical E....

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Literature Corpus work
12349e60-f941-5bdc-b7d0-6af25c08672c
DOI
10.1101/2020.05.22.110148
Open publication

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A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of <i>Escherichia coli</i> ST131DOI 10.1101/2020.05.22.110148
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