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A cynomolgus monkey E. coli urinary tract infection model confirms efficacy of new FimH vaccine candidates

19 Sept 2024

Abstract excerpt

ABSTRACT The increase in urinary tract infections (UTI) caused by antibiotic-resistant Escherichia coli requires the development of new therapeutic agents and prophylactic vaccines. To evaluate the efficacy of new lead candidates, we implemented a cynomolgus macaque UTI challenge model that mimics human uncomplicated cystitis in response to transurethral challenge with a multidrug-resistant (MDR) E. coli serotype...

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PMID: 39297649
DOI: 10.1128/iai.00169-24

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