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Article

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson's Disease Models.

Cell reports - 20 Feb 2018

Iannielli Angelo, Bido Simone, Folladori Lucrezia, Segnali Alice, Cancellieri Cinzia, Maresca Alessandra, Massimino Luca, Rubio Alicia, Morabito Giuseppe, Caporali Leonardo, Tagliavini Francesca, Musumeci Olimpia, Gregato Giuliana, Bezard Erwan, Carelli Valerio, Tiranti Valeria, Broccoli Vania

Abstract excerpt

Dysfunctions in mitochondrial dynamics and metabolism are common pathological processes associated with Parkinson's disease (PD). It was recently shown that an inherited form of PD and dementia is caused by mutations in the OPA1 gene, which encodes for a key player in mitochondrial fusion and structure. iPSC-derived neural cells from these patients exhibited severe mitochondrial fragmentation, respiration...

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Identifiers

PMID: 29466734
DOI: 10.1016/j.celrep.2018.01.089
PMCID: PMC5842028

Genes

OPA1

Provenance

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