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Article

Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease.

Stem cell reports - 9 Jun 2020

Yamaguchi Akihiro, Ishikawa Kei-Ichi, Inoshita Tsuyoshi, Shiba-Fukushima Kahori, Saiki Shinji, Hatano Taku, Mori Akio, Oji Yutaka, Okuzumi Ayami, Li Yuanzhe, Funayama Manabu, Imai Yuzuru, Hattori Nobutaka, Akamatsu Wado

Abstract excerpt

Parkinson disease (PD) is a neurodegenerative disorder caused by the progressive loss of midbrain dopaminergic neurons, and mitochondrial dysfunction is involved in its pathogenesis. This study aimed to establish an imaging-based, semi-automatic, high-throughput system for the quantitative detection of disease-specific phenotypes in dopaminergic neurons from induced pluripotent stem cells (iPSCs) derived from...

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Identifiers

PMID: 32470327
DOI: 10.1016/j.stemcr.2020.04.011
PMCID: PMC7355139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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