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Article

A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA.

Scientific reports - 13 Jun 2018

Little Daniel, Luft Christin, Mosaku Olukunbi, Lorvellec Maëlle, Yao Zhi, Paillusson Sébastien, Kriston-Vizi Janos, Gandhi Sonia, Abramov Andrey Y, Ketteler Robin, Devine Michael J, Gissen Paul

Abstract excerpt

Mitochondrial dysfunction is implicated in many neurodegenerative diseases including Parkinson's disease (PD). Induced pluripotent stem cells (iPSCs) provide a unique cell model for studying neurological diseases. We have established a high-content assay that can simultaneously measure mitochondrial function, morphology and cell viability in iPSC-derived dopaminergic neurons. iPSCs from PD patients with mutations...

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Source

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Identifiers

PMID: 29899557
DOI: 10.1038/s41598-018-27058-0
PMCID: PMC5998042

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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