Article
Neuron-based high-content assay and screen for CNS active mitotherapeutics.
Science advances - 1 Jan 2020
Varkuti Boglarka H, Kepiro Miklos, Liu Ze, Vick Kyle, Avchalumov Yosef, Pacifico Rodrigo, MacMullen Courtney M, Kamenecka Theodore M, Puthanveettil Sathyanarayanan V, Davis Ronald L
Abstract excerpt
Impaired mitochondrial dynamics and function are hallmarks of many neurological and psychiatric disorders, but direct screens for mitotherapeutics using neurons have not been reported. We developed a multiplexed and high-content screening assay using primary neurons and identified 67 small-molecule modulators of neuronal mitostasis (MnMs). Most MnMs that increased mitochondrial content, length, and/or health also...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.