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Article

AI-Driven Multi-Omics Integration of Synthetic Colon Adenocarcinoma for Cluster-Guided PROTAC Candidate Design Targeting KRASG12D.

International journal of molecular sciences - 22 Aug 2026

Elamin Khaled M, Elbashir Sara Mustafa Idris, Adam Ishag

Abstract excerpt

Colorectal cancer is a leading cause of cancer death, yet its molecular heterogeneity remains poorly translated into individualized treatment. We present a reproducible artificial intelligence (AI) framework that integrates multi-omics benchmarking, sample-level drug prioritization, E3 ubiquitin ligase selection, and shape-anchored Proteolysis Targeting Chimera (PROTAC) design for KRASG12D in colon adenocarcinoma...

Read the complete abstract on PubMed

Topics

Humans
Proteolysis Targeting Chimera
Colonic Neoplasms
Adenocarcinoma
Artificial Intelligence
Proto-Oncogene Proteins p21(ras)

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Multiomics

Mutation

Source

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Identifiers

PMID: 42737415
DOI: 10.3390/ijms27177511
PMCID: PMC13565430

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