Article

Conditioned Generative Modeling of Molecular Glues: A Realistic AI Approach for Synthesizable Drug-Like Molecules

2025-04-29

Abstract excerpt

Alzheimer’s disease (AD) is marked by the pathological accumulation of amyloid beta-42 (Aβ42), contributing to synaptic dysfunction and neurodegeneration. While extracellular amyloid plaques are well-studied, increasing evidence highlights intracellular Aβ42 as an early and toxic driver of disease progression. In this study, we present a novel, AI-assisted drug design approach to promote targeted degradation of Aβ...

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Literature Corpus work: 7158a0ed-ecfb-53e6-83a8-f7bbdca1b093
DOI: 10.20944/preprints202504.2454.v1

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