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Lipotoxic fingerprints in clinically relevant postoperative pancreatic fistula: fatty acid–driven cytotoxicity targets cells involved in anastomotic healing

2026-02-13

Abstract excerpt

<h4>Background & Aims</h4> Clinically relevant postoperative pancreatic fistula (CR-POPF) remains a major cause of morbidity following pancreatic surgery, potentially due to fatty acid release by lipase activity. This study investigated how the biochemical composition of CR-POPF effluents drives cellular injury and transcriptional stress responses. <h4>Methods</h4> Drain effluents from 14 patients undergoing pan...

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Literature Corpus work
68aa3a91-f7f7-55fb-b3b0-4bf82d8df0cd
DOI
10.64898/2026.02.12.705517
Open publication

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