Discovery of Chemical Tools for Polysorbate-Degradative Enzyme Control in Biopharmaceutical Upstream Process via Multi-Omic Profiling of Host Cell Clones

Abstract excerpt

Host cell proteins are process-related impurities in biotherapeutics and can potentially pose risks to patient safety and product quality. Specifically, certain host cell–derived enzymes, including lipases, can degrade the formulation excipient polysorbate (PS) in biopharmaceutical formulations, affecting drug product stability in liquid formulations. We leveraged multi-omics approaches, including transcriptomics,...

Topics

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• CAR-T cell therapy research
• Monoclonal and Polyclonal Antibodies Research
• Protein purification and stability
• Transgenic Plants and Applications
• Viral Infectious Diseases and Gene Expression in Insects
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

a8a06f14-e7c3-5434-8fb7-779efe98e92c

DOI

10.1101/2025.01.24.634759