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Article

Dysregulated pancreatic lipid phenotype, inflammation and cellular injury in a chronic ethanol feeding model of hepatic alcohol dehydrogenase-deficient deer mice.

Life sciences - 1 Jun 2023

Srinivasan Mukund P, Bhopale Kamlesh K, Caracheo Anna A, Kaphalia Lata, Popov Vsevolod L, Boor Paul J, Kaphalia Bhupendra S

Abstract excerpt

AIMS: Dysregulation of pancreatic fat and lipotoxic inflammation are common clinical findings in alcoholic chronic pancreatitis (ACP). In this study, we investigated a relationship between dysregulated pancreatic lipid metabolism and the development of injury in a chronic ethanol (EtOH) feeding model of hepatic alcohol dehydrogenase 1- deficient (ADH-) deer mice. METHODS: ADH- and hepatic ADH normal (ADH+) deer...

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PMID: 37030615
DOI: 10.1016/j.lfs.2023.121670

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