Article

Conditional deletion of <i>Ccl2</i> in smooth muscle cells does not reduce early atherosclerosis in mice

2023-08-07

Abstract excerpt

<h4>Background and aims</h4> C-C motif chemokine ligand 2 (CCL2) is a pro-inflammatory chemokine important for monocyte recruitment to the arterial wall and atherosclerotic plaques. Global knockout of Ccl2 reduces plaque formation and macrophage content in mice, but the importance of different plaque cell types in mediating this effect has not been resolved. Smooth muscle cells (SMCs) can adopt a potentially pro...

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Literature Corpus work: 68a9a645-1a9f-5c4a-97b1-1598b07ff9fa
DOI: 10.1101/2023.08.06.552177

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