Article

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

2017-11-02

Abstract excerpt

<h4>ABSTRACT</h4> Senescent cells interact with the surrounding microenvironment achieving diverse functional outcomes. In addition to autocrine and paracrine signalling mediated by factors of the senescence-associated secretory phenotype, we have recently identified that NOTCH1 can drive ‘lateral induction’ of a unique form of senescence in adjacent cells through specific induction of the NOTCH ligand JAG1. Here...

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Literature Corpus work: 68a44fc6-d3f0-515f-9706-39aae02d0ac9
DOI: 10.1101/212829

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