Article
Novel impact of the DNMT3A R882H mutation on GSH metabolism in a K562 cell model established by TALENs.
Oncotarget - 2 May 2017
Yang Li, Liu Ya'Nan, Zhang Na, Ding Xiao'Yi, Zhang Wei, Shen Ke'Feng, Huang Liang, Zhou Jian'Feng, Cui Sen, Zhu Zun'Min, Hu Zheng, Xiao Min
Abstract excerpt
DNA methyltransferase 3A (DNMT3A) mutations occurred in 18%~23% of acute myeloid leukemia (AML) patients, and were considered to be an adverse prognostic factor for adult de novo AML cases. However, the relevant molecular mechanism of the mutation in AML pathogenesis remains obscure. In this study, we established K562 and SKM1 cell model carrying the DNMT3A R882H mutation via transcription activator-like effector...
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