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Enzyme-Constrained Metabolic Modeling of the Tripartite Synapse Links Astrocyte-Neuron Lactate Shuttle to Lipid Trafficking and Redox Homeostasis

2026-06-19

Abstract excerpt

Neuron–astrocyte metabolic coupling sustains synaptic function through coordinated substrate exchange, redox homeostasis, and lipid handling, yet the systems-level mechanism remains poorly understood. Here, we developed an enzyme-constrained, genome-scale metabolic model of the mouse tripartite synapse to test whether protein allocation can reproduce the astrocyte–neuron lactate shuttle (ANLS). Starting from the i...

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Literature Corpus work: 6879ca7e-ef86-55e7-8cb1-0e84456eb452
DOI: 10.64898/2026.06.15.732277

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