Article
Mouse phenogenomics: the fast track to "systems metabolism".
Cell metabolism - 1 Dec 2005
Argmann Carmen A, Chambon Pierre, Auwerx Johan
Abstract excerpt
With the completion of the many genomes, genetics is positioned to meet physiology. In this review, we summarize the coming of "systems metabolism" in mammals through the use of the mouse, as a model system to study metabolism. Building on mouse genetics with increasingly sophisticated clinical and molecular phenotyping strategies has enabled scientists to now tackle complex biomedical questions, such as those...
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