Article
Massive parallel variant characterization identifies <i>NUDT15</i> alleles associated with thiopurine toxicity
2019-08-20
Abstract excerpt
As a prototype of genomics-guided precision medicine, individualized thiopurine dosing based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this class of drugs. Recently, NUDT15 deficiency was identified as a novel genetic cause of thiopurine toxicity, and NUDT15 -informed preemptive dose reduction is quickly adopted in clinical settings. To exhaustively identify pharmacogene...
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Identifiers and source
- Literature Corpus work
- 4fe63f41-6696-5d27-9b85-7e9a0ccc0b87
- DOI
- 10.1101/740837