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Article

Molecular dynamics simulations reveal the impact of NUDT15 R139C and R139H variants in structural conformation and dynamics.

Journal of biomolecular structure & dynamics - 1 Jan 2023

Gómez-Rubio Elena, Garcia-Marin Javier

Abstract excerpt

NUDT15, also known as MTH2, is a member of the NUDIX protein family that catalyzes the hydrolysis of nucleotides and deoxynucleotides, as well as thioguanine analogues. NUDT15 has been reported as a DNA sanitizer in humans, and more recent studies have shown that some genetic variants are related to a poor prognosis in neoplastic and immunologic diseases treated with thioguanine drugs. Despite this, the role of...

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PMID: 36907600
DOI: 10.1080/07391102.2023.2187626

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