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Article

Classification of VUS and unclassified variants in BRCA1 BRCT repeats by molecular dynamics simulation

1 Jan 2020

Abstract excerpt

Pathogenic mutation in BRCA1 gene is one of the most penetrant genetic predispositions towards cancer. Identification of the mutation provides important aspect in prevention and treatment of the mutation-caused cancer. Of the large quantity of genetic variants identified in human BRCA1 , substantial portion is classified as Variant of Uncertain Significance (VUS) or unclassified variants due to the lack of...

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PMID: 32257056
DOI: 10.1016/j.csbj.2020.03.013

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