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Article

Genome-wide association and Mendelian randomization analysis prioritizes bioactive metabolites with putative causal effects on common diseases

2020-08-04

Abstract excerpt

Bioactive metabolites are central to numerous pathways and disease pathophysiology, yet many bioactive metabolites are still uncharacterized. Here, we quantified bioactive metabolites using untargeted LC-MS plasma metabolomics in two large cohorts (combined N≈9,300) and utilized genome-wide association analysis and Mendelian randomization to uncover genetic loci with roles in bioactive metabolism and prioritize me...

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Literature Corpus work
2e3fd504-62f3-5529-8e04-4a402379f9dd
DOI
10.1101/2020.08.01.20166413
Open publication

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Genome-wide association and Mendelian randomization analysis prioritizes bioactive metabolites with putative causal effects on common diseasesDOI 10.1101/2020.08.01.20166413
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