Article

Pre-immunization with inactivated pathogens recapitulates adult human immune memory in laboratory mice

2022-10-18

Abstract excerpt

Laboratory mice show poor translation to humans within a range of pre-clinical fields, which might be due to their specific pathogen free (SPF) status. SPF mice have CD8 + effector memory T cell levels more comparable to newborn than to adult humans or pet shop mice. However, reintroducing pathogens would re-introduce diseases, and, therefore, research facilities should look for safer alternatives. We inactivated...

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Literature Corpus work: 68609399-0501-599e-b3f3-fd8518dfc959
DOI: 10.21203/rs.3.rs-2165344/v1

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