Article
Early life vaccination: Generation of adult-quality memory CD8+ T cells in infant mice using non-replicating adenoviral vectors.
Scientific reports - 8 Dec 2016
Nazerai Loulieta, Bassi Maria R, Uddback Ida E M, Holst Peter J, Christensen Jan P, Thomsen Allan R
Abstract excerpt
Intracellular pathogens represent a serious threat during early life. Importantly, even though the immune system of newborns may be characterized as developmentally immature, with a propensity to develop Th2 immunity, significant CD8+ T-cell responses may still be elicited in the context of optimal priming. Replication deficient adenoviral vectors have been demonstrated to induce potent CD8+ T-cell response in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.