Article

Dirty mice better recapitulate key features of mRNA vaccine immunogenicity observed in humans

2026-03-07

Abstract excerpt

Although specific pathogen free (SPF) mice have traditionally been used to test candidate vaccines, recent work has demonstrated that “dirty” mice with broad microbial exposure more appropriately recapitulate human immune responses. Using a model where lab mice are co-housed with pet store mice, we modeled SARS-CoV-2 mRNA vaccine responses in dirty and traditional SPF models. We found that dirty mice show reduced...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 253c5ee3-a94e-5dcd-af63-cff1e1967cde
DOI: 10.64898/2026.03.07.709392

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dirty mice better recapitulate key features of mRNA vaccine immunogenicity observed in humansDOI 10.64898/2026.03.07.709392Read

Naturally transmitted mouse viruses highlight the heterogeneity of virus transmission dynamics in the dirty mouse modelSemantic proximity Read

A gavage-fomite based method to generate mouse models with natural microbiotaSemantic proximity Read

Effects of different environments and microbial exposures on the adult immune system of the C57BL/6 laboratory mouse strainSemantic proximity Read

Animal models for COVID-19: advances, gaps and perspectivesSemantic proximity Read

CVnCoV protects human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2Semantic proximity Read

CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2Semantic proximity Read

SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19Semantic proximity Read

Modeling Infectious Disease in Mice: Co-Adaptation and the Role of Host-Specific IFNγ ResponsesSemantic proximity Read

B.1.1.7 and B.1.351 variants are highly virulent in K18-ACE2 transgenic mice and show different pathogenic patterns from early SARS-CoV-2 strainsSemantic proximity Read

Omicron Subvariants Infection Kinetics and Nirmatrelvir Efficacy in Transgenic K18-hACE2 MiceSemantic proximity Read

Ipsilateral or contralateral boosting of mice with mRNA vaccines confers equivalent immunity and protection against a SARS-CoV-2 Omicron strainSemantic proximity Read

Host immune responses associated with SARS-CoV-2 Omicron infection result in protection or pathology during reinfection depending on mouse genetic background.Semantic proximity Read