Article

Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in Sugar Porter family

2020-02-26

Abstract excerpt

The human glucose transporters GLUT1 and GLUT3 have a central role in glucose uptake as canonical members of the Sugar Porter (SP) family. GLUT1 and GLUT3 share a fully conserved substrate-binding site with identical substrate coordination, but differ significantly in transport affinity in line with their physiological function. Here we present a 2.4 Å crystal structure of GLUT1 in an inward open conformation and...

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Literature Corpus work: df5b5497-0e2b-53bf-bc2f-7d5ea4a6231f
DOI: 10.1101/2020.02.24.962258

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