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Article

Effect of the R126C mutation on the structure and function of the glucose transporter GLUT1: A molecular dynamics simulation study.

Journal of molecular graphics & modelling - 1 Nov 2022

Liu Xiaoliu, Liang Luguang, Wu Bodeng, Zhang Xin, Zeng Xiaoman, Deng Yurong, Peng Bin, Zhang Xiuming, Zheng Lei

Abstract excerpt

Glucose transporter 1 (GLUT1) is responsible for basal glucose uptake and is expressed in most tissues under normal conditions. GLUT1 mutations can cause early-onset absence epilepsy and myoclonus dystonia syndrome (MDS), with MDS potentially lethal. In this study, the effect of the R126C mutation, which is associated with MDS, on structural stability and substrate transport of GLUT1 was investigated. Various...

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Biological Transport
Glucose
Glucose Transporter Type 1
Molecular Dynamics Simulation
Mutation

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PMID: 35671570
DOI: 10.1016/j.jmgm.2022.108227

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