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Structure-based modelling and dynamics of MurM, a <i>Streptococcus pneumoniae</i> penicillin resistance determinant that functions at the cytoplasmic membrane interface

2020-06-18

Abstract excerpt

MurM is an aminoacyl-tRNA dependant ligase that aminoacylates the Lipid II peptidoglycan precursor, in the human pathogen Streptococcus pneumoniae . MurM is required for the generation of branched peptidoglycan precursors enabling indirect cross-links in the peptidoglycan and is found to be essential for penicillin resistance. In this study we have solved the X-ray crystal structure of Staphylococcus aureus FemX...

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Literature Corpus work
68441ecd-11bf-538b-a79e-3b40988897a6
DOI
10.1101/2020.06.18.158840
Open publication

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