Article

The effect of MurM and a branched cell wall structure on penicillin resistance in <i>Streptococcus pneumoniae</i>

2025-04-05

Abstract excerpt

The aminoacyltransferase MurM is an important penicillin resistance determinant in Streptococcus pneumoniae . This enzyme attaches a serine or alanine to the dipeptide side chain of lipid II, resulting in branched muropeptides that can be crosslinked to stem peptides in the peptidoglycan layer by penicillin binding proteins (PBPs). Deletion of murM results in only linear muropeptides, and more importantly a sign...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f839f830-1b3c-5304-a379-86451e9dcb32
DOI: 10.1101/2025.04.05.647355

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The effect of MurM and a branched cell wall structure on penicillin resistance in <i>Streptococcus pneumoniae</i>DOI 10.1101/2025.04.05.647355Read

The murMN operon: a functional link between antibiotic resistance and antibiotic tolerance in Streptococcuspneumoniae.Semantic proximity Read

Structure-based modelling and dynamics of MurM, a <i>Streptococcus pneumoniae</i> penicillin resistance determinant that functions at the cytoplasmic membrane interfaceSemantic proximity Read

Functional analysis of Streptococcus pneumoniae MurM reveals the region responsible for its specificity in the synthesis of branched cell wall peptides.Semantic proximity Read

The role of murMN operon in penicillin resistance and antibiotic tolerance of Streptococcus pneumoniae.Semantic proximity Read

A Molecular Link between Cell Wall Modification and Stringent Response in a Gram-positive BacteriaSemantic proximity Read

Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniae.Semantic proximity Read

A bacterial cell wall repair and modification system to resist host antibacterial factorsSemantic proximity Read

Divergent LD-transpeptidase-independent effects of peptidoglycan carboxypeptidases on intrinsic β-lactam and vancomycin resistanceSemantic proximity Read

Effects of low PBP2b levels on cell morphology and peptidoglycan composition in Streptococcus pneumoniae R6.Semantic proximity Read

Drastic changes in the peptidoglycan composition of penicillin resistant laboratory mutants of Streptococcus pneumoniae.Semantic proximity Read

Altered murein composition in a DD-carboxypeptidase mutant of Streptococcus pneumoniae.Semantic proximity Read

Mosaic genes and their role in penicillin‐resistant <i>Streptococcus pneumoniae</i> (minireview)Semantic proximity Read