Analysis of Structure and Function of Putative Surface-Exposed Proteins Encoded in the<i>Streptococcus pneumoniae</i>Genome: A Bioinformatics-Based Approach to Vaccine and Drug Design

Abstract excerpt

Streptococcus pneumoniae is the most common cause of fatal community-acquired pneumonia, middle ear infection, and meningitis. The prevention and treatment of this infection have become a top priority for the medical-scientific community. The present polysaccharide-based vaccine used to immunize susceptible hosts is only approximately 60% effective and is ineffective in children younger than 2 years of age. The...

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