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Article

Detection of Transport Intermediates in the Peptidoglycan Flippase MurJ Identifies Residues Essential for Conformational Cycling.

Journal of the American Chemical Society - 25 Mar 2020

Rubino Frederick A, Mollo Aurelio, Kumar Sujeet, Butler Emily K, Ruiz Natividad, Walker Suzanne, Kahne Daniel E

Abstract excerpt

Bacterial cell wall synthesis is an essential process in bacteria and one of the best targets for antibiotics. A critical step on this pathway is the export of the lipid-linked cell wall monomer, Lipid II, by its transporter MurJ. The mechanism by which MurJ mediates the transbilayer movement of Lipid II is not understood because intermediate states of this process have not been observed. Here we demonstrate a...

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Identifiers

PMID: 32129990
DOI: 10.1021/jacs.9b12185
PMCID: PMC7192318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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